All You Need to Know About Harvoni® as a Treatment for Hepatitis C
The medications and procedure of treatment for Hepatitis C has been quite challenging in the past. The treatment regimen was mostly marked by multiple medicines and intricate dozing, making it difficult for patients to tolerate the treatment procedure. The medication mostly consisted of a combination of peginterferon and ribavirin. This medicine had a cure rate of about 50% only and also had greater side effects. The introduction of Harvoni®, a combination of two drugs- ledipasvir and sofosbuvir, brought a breakthrough in the treatment of Hepatitis C. This new medication, devoid of interferon or any complicated regimen, was the first cure devised that consisted of just one pill per day. Harvoni® also has a cure rate of a whooping 96-99% for patients with Hepatitis C genotype 1 and is a recommended medicine for patients with chronic Hepatitis C genotype 1, 4, 5, or 6 infections. It is also a great option for patients who are co-infected with HIV.
Structure and mechanism of Harvoni®
The interferon and ribavirin free Harvoni® is the first FDA-approved regimen for Hepatitis C. While the ledipasvir component of Harvoni® inhibits the viral phosphoprotein named HCV NS5A and stops the replication, assembly, and secretion of the virus, Sofosbuvir plays the role of a nucleotide analog inhibitor of the key enzyme mediating HCV RNA replication- hepatitis C virus NS5B polymerase. Additionally, the triphosphate form of sofosbuvir (GS-461203) carries out viral chain termination by mimicking the natural cellular uridine nucleotide and incorporating the HCV RNA polymerase into the elongating RNA primer strand.
How much does it cost and where to get it
If you get Harvoni® on the wholesale acquisition cost (WAC), the price can be about $1125 per pill. The medication is available at different rates depending on the course of the treatment. It can cost $63,000 for an 8-week course, $94,500 for a 12-week course, and $189,000 for a 24-week course. Gilead Sciences has a monopoly in the market for Harvoni® for Hepatitis C treatment. They also offer a special patient assistance program for patients suffering from Hepatitis C and who do not have insurance or are not covered through Medicaid or Medicare. One can save up more than $20,000 through the company’s co-pay program which covers up to 25% of the 12-week long treatment.
Possible Side Effects of Harvoni®
Though clinical trials have deemed this combination of Ledipasvir and sofosbuvir as quite safe and devoid of any major side effects, there can still be some effects of the medicine according to different situations.
- Slow Heart Rate– If you consume Harvoni® along with a medicine for heart problems such as amiodarone (Cordarone®, Nexterone®, Pacerone®), it may cause a slow heart rate, leading to death or need for a pacemaker in some cases. If you notice symptoms such as weakness, chest pains, fainting, dizziness, and so on, you should immediately get medical help.
- Hepatitis B virus reactivation– If you ever had hepatitis B, the virus could become active again during or after your treatment with Harvoni®. This may further lead to major problems of the liver including liver failure and death.
- Other side effects– The other minor and common side effects of Harvoni® include headache, tiredness, weakness, and so on.
Thus, though before starting the treatment your healthcare provider will carry out the necessary tests to check for other infections or medical conditions, you should duly inform them if you ever had liver problems other than Hepatitis C infection, liver transplant, HIV, severe kidney problems, or if you are pregnant or breastfeeding or plan to do so, and about the other medications you take.
I would like to introduce our company to the many Hepatitis C sufferers who don’t have the insurance or time to deal with the constant delays of their insurance company.The goal of Surcation.com is to assist as many Americans as possible to be free of Hep C without insurance delays and excuses. The medical trip including medication and RT airfare is still a savings of over 90% from the prescriptive price in the United States.
Our medical tour is for seven days. There are so many historical sites to visit and the food is fabulous.
Contact me if you know anyone is suffering from Hepatitis C
Email : [email protected]
Address : 1274 S. Fortuna Rd.Yuma, AZ 85367